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Study details
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At-BC8-B10 Trial Before Stem Cell Transplant

Fred Hutchinson Cancer Center
NCT IDNCT03128034ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

75

Study length

about 11 years

Ages

18–75

Locations

1 site in WA

About this study

This trial is testing a treatment called At-BC8-B10 before donor stem cell transplant in people with high-risk leukemia. The goal is to find the best dose of this treatment and see how it affects patients.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Pretargeted Radioimmunotherapy
  • 2.Receive Total-Body Irradiation
  • 3.Take Cyclosporine
  • +3 more
PhasePhase 1/Phase 2
DrugCyclosporine
Routeinjection
Primary goalIncidence of grades III/IV Bearman regimen-related toxicity

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

ciclosporin, Antineoplastic Agent [TC] (Nucleic Acid Synthesis Inhibitors), Immunological Agents (Enzyme Inhibitors)

Drug routes

injection, intravenous, injection (Injection)

Endpoints

Primary: Incidence of grades III/IV Bearman regimen-related toxicity

Secondary: Disease-free survival, Non-relapse mortality, Overall survival

Procedures

diagnostic, imaging, radiation

Body systems

Oncology