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Study details
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Blinatumomab, Methotrexate, Cytarabine, and Ponatinib Trial

M.D. Anderson Cancer Center
NCT IDNCT03263572ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

90

Study length

about 10 years

Ages

18+

Locations

1 site in TX

About this study

This trial is testing how well blinatumomab, methotrexate, cytarabine, and ponatinib work in treating patients with Philadelphia chromosome-positive or BCR-ABL positive acute lymphoblastic leukemia that has returned or not responded to treatment. This treatment involves a combination of immunotherapy and chemotherapy drugs.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Blinatumomab
  • 2.Take Cytarabine
  • 3.Take Methotrexate
  • +1 more
PhasePhase 2
DrugBlinatumomab
Routeinjection
Primary goalEvent-free survival

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

blinatumomab, cytarabine, methotrexate, ponatinib

Drug routes

injection, intravenous, injection (Injection), oral (Oral Tablet)

Endpoints

Primary: Event-free survival, Overall response rate (ORR) in relapsed/refractory ALL, Overall survival, Relapse-free survival

Body systems

Oncology