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Study details
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Evaluating New Breast Cancer Treatments

Hoffmann-La Roche
NCT IDNCT03424005ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

792

Study length

about 13 years

Ages

18+

Locations

16 sites in CA, CO, FL +5

About this study

Researchers are testing multiple treatment combinations in people with advanced or locally advanced breast cancer. The trial will be done in two stages, starting with a group of participants who have never received immunotherapy and then including those who have progressed on previous treatments. Participants may receive different treatment combinations during the second stage if they experience disease progression.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Abemaciclib
  • 2.Take Atezolizumab
  • 3.Take Atirmociclib
  • +3 more
PhasePhase 1/Phase 2
DrugAbemaciclib
Routeoral
Primary goalObjective Response Rate (ORR)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

abemaciclib, atezolizumab, cdk inhibitor, bevacizumab, capecitabine, carboplatin, empagliflozin (SGLT2 inhibitor; increases glucose excretion in urine), eribulin

Drug routes

oral (Oral Tablet), injection (Injection), infusion, injection, oral, oral (Oral Capsule)

Endpoints

Primary: Objective Response Rate (ORR)

Secondary: Disease Control Rate (DCR), Duration of Response (DOR), Overall Survival (OS), Overall Survival (at specific time-points), Percentage of Participants with Adverse Events, Progression Free Survival (PFS)

Body systems

Oncology