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Study details
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Ocrelizumab for Psychosis by Autoimmunity

The Methodist Hospital Research Institute
NCT IDNCT03971487ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

40

Study length

about 6.1 years

Ages

18–35

Locations

1 site in TX

About this study

This trial is testing whether ocrelizumab, a medication that suppresses auto-antibodies, can help people with psychosis caused by autoimmune factors. Participants will receive ocrelizumab infusions and undergo evaluations to assess the treatment's effects on their symptoms and cognitive function. It aims to determine if this approach is effective in managing psychosis related to auto-antibody production.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Physical and neuro-cognitive evaluations
  • 2.Participate in Psychosis and cognitive assessments
  • 3.Receive Ocrelizumab infusion
  • +1 more
PhasePhase 1/Phase 2
DrugOcrelizumab infusion
Routeinjection

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low10%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

ocrelizumab

Drug routes

injection, intravenous, infusion

Endpoints

Secondary: Score on quality of life scales for psychiatric patients

Procedures

diagnostic

Body systems

Psychiatry / Mental Health