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Study details
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A Study Comparing Chemotherapy to CPX-351 and/or Gilteritinib for Acute Myeloid Leukemia

Children's Oncology Group
NCT IDNCT04293562ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

1,186

Study length

about 8.9 years

Ages

≤21

Locations

185 sites in AL, AR, AZ +44

About this study

Researchers are testing whether a treatment with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib, in addition to standard chemotherapy, improves outcomes for people newly diagnosed with acute myeloid leukemia. The trial will compare the effects of this new treatment approach to standard chemotherapy alone.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Fludeoxyglucose F-18
  • 2.Questionnaire Administration
  • 3.Take Asparaginase Erwinia chrysanthemi
  • +3 more
PhasePhase 3
DrugAsparaginase Erwinia chrysanthemi
Routeinjection
Primary goalEvent-free survival (EFS)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS, cytarabine, Antineoplastic Agent [TC] (DNA Polymerase Inhibitors), Cardiovascular Agent [TC] (Chelating Activity), etoposide, fludeoxyglucose (18F), gemtuzumab ozogamicin, Antineoplastic Agent [TC] (Receptor Tyrosine Kinase Inhibitors)

Drug routes

injection (Injection), infusion, injection, intravenous, oral (Oral Tablet)

Endpoints

Primary: Event-free survival (EFS)

Secondary: Incidence of adverse events, Overall survival (OS)

Procedures

diagnostic, biopsy, imaging

Body systems

Oncology