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Study details
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Combination of Novel Therapies for CKD Comorbid Depression

Stony Brook University
NCT IDNCT04422652ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

201

Study length

about 6.5 years

Ages

18+

Locations

4 sites in NY, TX, WA

About this study

This trial is testing if combining behavioral therapy, bupropion, and clinical management with a treatment improves outcomes in people with chronic kidney disease (CKD) who also have depression. The goal is to find better ways to treat depression in this specific patient population.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Clinical Management
  • 2.Participate in Behavioral activation therapy
  • 3.Take Bupropion
  • +1 more
PhasePhase 2
DrugBupropion

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

bupropion

Endpoints

Secondary: Fatigue assessed by the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale, High sensitivity C-reactive protein, Serious adverse events, Serious adverse events with monotherapy, Sleep assessed by the Insomnia Severity Index (ISI)

Body systems

Psychiatry / Mental Health, Renal