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Study details
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Explosive Synchronization of Brain Network Activity in Chronic Pain

University of Michigan
NCT IDNCT04606095ClinicalTrials.gov data as of Apr 2026
Target enrollment

150

Study length

about 5.3 years

Ages

19–74

Locations

1 site in MI

About this study

Researchers are testing whether explosive synchronization and its treatment with non-invasive brain stimulation can help people with fibromyalgia. The trial will measure brain activity, connectivity, and response to pain in both healthy volunteers and people with fibromyalgia. It also involves a longitudinal assessment of fibromyalgia patients undergoing HD-tDCS or ES HD-tDCS.

Based on ClinicalTrials.gov records.

What participants do

  • 1.EEG
  • 2.Neuroimaging EEG/fMRI (Aim 1)
  • 3.Neuroimaging EEG/fMRI (Aim 3)
  • +2 more

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low13%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Secondary: Aim 1: Insular Glx (glutamate + glutamine) using proton magnetic resonance spectroscopy obtained at Visit 2, Aim 1: Resting brain functional connectivity using functional magnetic resonance imaging obtained at Visit 2

Procedures

diagnostic, imaging

Devices

therapeutic, diagnostic

Body systems

Musculoskeletal