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Study details
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CAR-T Cells for HIV Infection

Steven Deeks
NCT IDNCT04648046ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

18

Study length

about 8.8 years

Ages

18–65

Locations

2 sites in CA

About this study

This trial is testing a new treatment called LVgp120duoCAR-T cells to see if it can help people with HIV. The treatment involves pausing HIV medications temporarily after receiving the CAR-T cells. Participants will be given either a low or high dose of these cells, and some may also receive cyclophosphamide before the infusion.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Analytic Treatment Interruption
  • 2.Receive LVgp120duoCAR-T cells, high dose
  • 3.Receive LVgp120duoCAR-T cells, low dose
  • +1 more
PhasePhase 1/Phase 2
DrugCyclophosphamide
Routeinfusion
Primary goalNumber of participants reporting a new Grade 3 or greater adverse event that is definitely, probably, or possibly related to study treatment within 1 year of product administration

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands)

Drug routes

infusion

Endpoints

Primary: Number of participants reporting a new Grade 3 or greater adverse event that is definitely, probably, or possibly related to study treatment within 1 year of product administration.

Body systems

Immune, Infectious