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Study details
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Dual Frequency Stimulation in Parkinson's Disease

University of California, Davis
NCT IDNCT04650932ClinicalTrials.gov data as of Apr 2026
Target enrollment

10

Study length

about 3.7 years

Ages

18+

Locations

1 site in CA

About this study

This trial is testing a new way to treat Parkinson's disease using deep brain stimulation. It involves stimulating both the dorsal and ventral regions of the subthalamic nucleus with different frequencies. The goal is to see if this approach can improve motor symptoms while minimizing cognitive side effects.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Use Deep brain stimulation
Primary goalMean Change from Baseline in Cognitive Performance Scores on the Montreal Cognitive Assessment - Blind (MoCA)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low8%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Mean Change from Baseline in Cognitive Performance Scores on the Montreal Cognitive Assessment - Blind (MoCA), Mean Change from Baseline in Depression Scores on the CES-D Short Version (CES-D-R10), Mean Change from Baseline in Depression Scores on the Center for Epidemiologic Studies Depression Scale (CES-D), Mean Change from Baseline in Impulsiveness Scores on the Barratt Impulsiveness Scale (BIS-11), Mean Change from Baseline in Motor and Non-Motor Aspects of Daily Living Scores on Parts I and II of the MDS-UPDRS, Mean Change from Baseline in Movement Scores on Part III of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Mean Change from Baseline in Neuropsychiatric Inventory (NPI)

Secondary: Mean Change from Baseline in Decision-Making Scores on Probabilistic Gambling Task, Mean Change from Baseline in Inter-Temporal Choice Scores on a Temporal Discounting Task, Mean Change from Baseline in Verbal Fluency Scores on Word Generation Task

Devices

implantable

Body systems

Neurology