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Study details
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Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Vanderbilt University Medical Center
NCT IDNCT04801589ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

372

Study length

about 5.4 years

Ages

0.843834922875406–11

Locations

1 site in TN

About this study

This trial is testing whether a specific sedation approach, using dexmedetomidine and midazolam, can reduce delirium and improve outcomes for children on ventilators. The goal is to determine the best sedative medication to help these vulnerable patients recover more fully after critical illness.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Dexmedetomidine
  • 2.Take Midazolam
PhasePhase 3
DrugDexmedetomidine

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low8%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

dexmedetomidine, midazolam (Benzodiazepine; short-acting)

Drug routes

injection

Endpoints

Secondary: Functional status, Incidence of post-traumatic stress symptoms in patients and parents/caregivers, Mortality

Body systems

Psychiatry / Mental Health