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Study details
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Exercise Primed Stroke Rehabilitation Trial

VA Office of Research and Development
NCT IDNCT04877444ClinicalTrials.gov data as of Apr 2026
Phase

EARLY_PHASE1

Target enrollment

40

Study length

about 4.6 years

Ages

50–90

Locations

1 site in SC

About this study

Researchers are testing whether combining aerobic exercise with physical rehabilitation improves physical and mental function in stroke survivors. The trial will examine the effects of this combined intervention on multiple aspects of stroke recovery, aiming to advance rehabilitative care for Veteran stroke survivors.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Aerobic exercise
  • 2.Participate in Lower extremity stretching
  • 3.Use Duck Duck Punch
PhaseEARLY_Phase 1
Primary goalChange from baseline upper extremity impairment assessed by the Fugl Meyer Upper Extremity Assessment (FMA-UE)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low10%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Change from baseline upper extremity impairment assessed by the Fugl Meyer Upper Extremity Assessment (FMA-UE)

Secondary: Change from baseline cognitive function assessed by National Institutes of Health Toolbox - Cognition Battery (NIHTB-CB), Change from baseline depressive symptoms assessed by the Geriatric Depression Scale (GDS), Change from baseline health related quality of life assessed by the Stroke Impact Scale (SIS), Change from baseline locomotor function assessed by self-selected walking (SSWS) speed and six-minute walk test (6MWT), Change from baseline neuroplastic potential, Change from baseline peripheral plasma and serum brain-derived neurotrophic factor (BDNF), Change from baseline upper extremity motor function assessed by the Wolf Motor Function Test (WMFT)

Body systems

Neurology