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Study details
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CAR-T Followed by Bispecific Antibodies

Abramson Cancer Center at Penn Medicine
NCT IDNCT04889716ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

42

Study length

about 5.7 years

Ages

18+

Locations

2 sites in NE, PA

About this study

Researchers are testing the safety and effectiveness of mosunetuzumab or a combination of obinutuzumab and glofitamab after CAR T-cell treatment in patients with DLBCL. The trial will last for approximately 2 years.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take glofitamab
  • 2.Take mosunetuzumab
  • 3.Take obinutuzumab
PhasePhase 2
Drugglofitamab
Primary goalAssessment of the percentage of subjects who experience hematologic dose limiting toxicity associated with early administration of Mosunetuzumab and glofitimab following SOC CAR-T Cell therapy in patients who stop therapy after 2 cycles

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

glofitamab, mosunetuzumab, obinutuzumab

Drug routes

injection, intravenous

Endpoints

Primary: Assessment of the percentage of subjects who experience hematologic dose limiting toxicity associated with early administration of Mosunetuzumab and glofitimab following SOC CAR-T Cell therapy in patients who stop therapy after 2 cycles., Assessment of the percentage of subjects who experience non-hematologic dose limiting toxicity associated with early administration of glofitimab following SOC CAR-T Cell therapy., Assessment of the percentage of subjects who experienced non-hematologic dose limiting toxicity associated with early administration of Mosunetuzumab following SOC CAR-T Cell therapy.

Body systems

Oncology