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Study details
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Reducing Opioid Mortality in Illinois

University of Chicago
NCT IDNCT04925427ClinicalTrials.gov data as of Apr 2026
Target enrollment

1,500

Study length

about 5.1 years

Ages

18+

Locations

5 sites in IL

About this study

This trial is testing two ways to help people who have used opioids and are released from jail or prison. One way is case management with peer recovery support, and the other is giving naloxone (an opioid overdose reversal drug) only. The goal is to see which approach works best at reducing deaths related to opioid use.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Case Management and Peer Recovery
  • 2.Participate in Naloxone-Only
DrugNaloxone-Only

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low5%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

opioid antagonist (Opioid antagonist; blocks opioid receptors)

Endpoints

Secondary: All-cause mortality, Opioid Use Disorder (OUD) Symptoms, Patient Reported Outcomes Measurement Information System, Social cost of re-arrest and associated offenses, Social cost of self reported crime, Stimulant Use Disorder Symptoms

Body systems

Psychiatry / Mental Health