Skip to content
Study details
Enrolling now

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Hoffmann-La Roche
NCT IDNCT04929223ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

542

Study length

about 7 years

Ages

18+

Locations

30 sites in AL, AZ, CA +14

About this study

This trial is testing different treatments, including drugs and immunotherapy, to see if they are safe and effective for people with advanced colorectal cancer whose tumors have specific biomarkers. Participants will be assigned to treatment arms based on their biomarker results.

Based on ClinicalTrials.gov records.

What participants do

  • 1.FoundationOne®Liquid CDx
  • 2.Take Atezolizumab
  • 3.Take Bevacizumab
  • +3 more
PhasePhase 1
DrugAtezolizumab
Routeinjection
Primary goalObjective Response Rate

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

atezolizumab, bevacizumab, cetuximab, Antineoplastic Agent [TC] (Phosphoinositide 3-Kinase alpha Inhibitors), monoclonal antibody

Drug routes

injection (Injection), infusion, oral (Oral Tablet)

Endpoints

Primary: Objective Response Rate

Secondary: Disease Control Rate, Duration of Response, Percentage of Participants with Adverse Events (AEs)

Body systems

Oncology