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Study details
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Two Step Haplo With Radiation Conditioning

Thomas Jefferson University
NCT IDNCT05031897ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

63

Study length

about 11 years

Ages

18+

Locations

1 site in PA

About this study

This trial is testing whether a modified conditioning regimen, using radiation and chemotherapy, can reduce treatment-related mortality (TRM) in adults undergoing hematopoietic stem cell transplant (HSCT) for certain blood cancers. This approach involves two steps: first, lower-intensity treatments are given before the transplant, followed by HSCT to cure the cancer.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Donor Lymphocyte Infusion
  • 2.Receive Total-Body Irradiation
  • 3.Take Cyclophosphamide
  • +3 more
PhasePhase 2
DrugCyclophosphamide
Routeinfusion

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low11%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine, melphalan, Immunological Agents (Enzyme Inhibitors), tacrolimus

Drug routes

infusion, intravenous, injection

Procedures

biopsy, diagnostic, radiation

Body systems

Oncology