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Study details
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An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Karuna Therapeutics, Inc., a Bristol Myers Squibb company
NCT IDNCT05304767ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

280

Study length

about 4 years

Ages

18–65

Locations

79 sites in AR, AZ, CA +20

About this study

Researchers are testing the safety and tolerability of a treatment called KarXT, which contains xanomeline and trospium chloride, for people with schizophrenia who haven't responded well to their current medication. The trial will last 1473 days and involve about 280 participants.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Xanomeline and Trospium Chloride Capsules
PhasePhase 3
DrugTrospium Chloride Capsules
Routeoral
Primary goalIncidence of treatment-emergent adverse events (TEAEs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low10%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

trospium, Antipsychotic Agent [TC] (Cholinergic Muscarinic Agonists)

Drug routes

oral

Endpoints

Primary: Incidence of treatment-emergent adverse events (TEAEs)

Secondary: Incidence of TEAEs leading to discontinuation of study drug, Incidence of serious treatment-emergent adverse events (TEAEs)

Body systems

Psychiatry / Mental Health