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Study details
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ComboMATCH Screening Trial

National Cancer Institute (NCI)
NCT IDNCT05564377ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

2,900

Study length

about 7.2 years

Ages

All ages

Locations

476 sites in AK, AL, AR +41

About this study

This trial is testing a new way to treat cancer by matching it to the patient's unique genetic makeup. The goal of this screening trial is to identify patients who might benefit from targeted therapies based on their tumor's specific genetic mutations. It aims to find treatments that could control tumors and help doctors plan better treatment for people with locally advanced or advanced solid tumors.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Panitumumab
  • 2.Take Alpelisib
  • 3.Take Binimetinib
  • +3 more
PhasePhase 2
DrugAlpelisib
Routeoral

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low4%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

alpelisib, binimetinib, fluorouracil (Antimetabolite; mimics uracil to disrupt DNA/RNA in cancer cells), fulvestrant, Antidotes, Deterrents, and Toxicologic Agents (Enzyme Interactions), Antineoplastic Agent [TC] (Kinase Inhibitors), Antineoplastic Agent [TC] (Bcr-Abl Tyrosine Kinase Inhibitors), olaparib

Drug routes

oral (Oral Tablet), oral (Oral Capsule), injection, injection (Injection), oral, intravenous

Procedures

biopsy, diagnostic, imaging

Body systems

Oncology