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Study details
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A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Hoffmann-La Roche
NCT IDNCT05595642ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

1,290

Study length

about 4.2 years

Ages

40–80

Locations

80 sites in AL, AR, AZ +24

About this study

Researchers are testing astegolimab, a medication, compared to placebo in people with COPD who are former or current smokers and have had frequent flare-ups. The trial will last for 1533 days.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Astegolimab
  • 2.Take Placebo
PhasePhase 3
DrugAstegolimab

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

monoclonal antibody

Endpoints

Secondary: Absolute change from baseline in health-related quality of life (HRQoL) at Week 52 as assessed through the St. George's Respiratory Questionnaire-COPD (SGRQ-C) total score, Absolute change from baseline in post-bronchodilator forced expiratory volume (FEV1) at Week 52, Absolute change from baseline in the Evaluating Respiratory Symptoms in Chronic Obstructive Pulmonary Disease (E-RS:COPD) total score at Week 52, Proportion of participants with improvement in HRQoL at Week 52

Body systems

Respiratory