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Study details
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A Phase 1/2 Trial of VX-522 in People with Cystic Fibrosis

Vertex Pharmaceuticals Incorporated
NCT IDNCT05668741ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

39

Study length

about 4.2 years

Ages

18–65

Locations

24 sites in AL, CA, CO +15

About this study

Researchers are testing the safety and how well a treatment called VX-522 works in people with cystic fibrosis who haven't responded to other treatments. The trial will last for about 1535 days.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take IVA
  • 2.Take VX-522 mRNA therapy
PhasePhase 1/Phase 2
Primary goalSafety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low7%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Secondary: MAD: Change From Baseline in Percent Predicted Forced Expiratory Volume in 1 Second (ppFEV1), MAD: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Body systems

Respiratory