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Study details
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A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis

Hoffmann-La Roche
NCT IDNCT05704361ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

129

Study length

about 5.9 years

Ages

18–65

Locations

5 sites in CA, CT, FL +2

About this study

Researchers are testing a treatment called RO7121932. The trial will be given intravenously (IV) or subcutaneously (SC). The goal is to see if it's safe and how the body processes this treatment in people with multiple sclerosis.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive RO7121932 IV
  • 2.Take RO7121932 SC
PhasePhase 1
Routeinfusion
Primary goalParts 1, 2, and 3: Change From Baseline in Suicide Risk as Assessed Using the Columbia-Suicide Severity Rating Scale (C-SSRS)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low14%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug routes

infusion, subcutaneous

Endpoints

Primary: Parts 1, 2, and 3: Change From Baseline in Suicide Risk as Assessed Using the Columbia-Suicide Severity Rating Scale (C-SSRS), Parts 1, 2, and 3: Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) With Severity of AEs Measured According to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5 (NCI CTCAE V5), Parts 2 and 3: Percentage of Participants With Local Injection-site Reaction Using Local Injection-site Symptom Assessment (LISSA), Parts 2 and 3: Percentage of Participants With Local Pain at the Site of Injection Assessed Using the Visual Analog Scale (VAS)

Secondary: Part 1: Total Body Clearance (CL) Of RO7121932, Parts 1 and 2: AUC From Time 0 to Infinity (AUCinf), Parts 1 and 3: Change From Baseline in B-cell Frequencies in CSF, Parts 1, 2 and 3 (Week 1 and Week 4): Maximum Observed Serum Concentration (Cmax) of RO7121932, Parts 1, 2 and 3 (Week 1 and Week 4): Time to Maximum Observed Concentration (Tmax) of RO7121932, Parts 1, 2 and 3: Apparent Terminal Half-Life (T1/2) of RO7121932, Parts 1, 2, and 3: Change From Baseline in B-cell Frequencies in Blood, Parts 2 and 3 (Week 4): Apparent Clearance (CL/F) of RO7121932

Body systems

Neurology