Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Phase 4
900
about 3.7 years
18+
6 sites in MI, MO, NC +2
About this study
This trial is testing two different ways to manage pain after surgery. Participants who have gallbladder removal, hernia repair, or breast lump removal will be included. Eligible people will be randomly assigned to either a group taking NSAIDs plus acetaminophen, or a group taking low-dose opioids plus acetaminophen. The goal is to compare the effectiveness and safety of these two approaches.
Based on ClinicalTrials.gov records.
What participants do
- 1.Take Acetaminophen
- 2.Take NSAID
- 3.Take Opioid
Participation effort
Estimated from trial records. Details can vary by site.
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
paracetamol (Reduces fever and pain (mechanism not fully understood))
oral
Primary: Pain intensity based on Brief Pain Inventory (BPI) pain intensity score at the surgical site over 7 days post surgery, Safety outcome - number and severity of any adverse medication-related symptoms over 7 days post surgery
Secondary: Acute pain based on The Michigan Body Map, Chronic pain based on Body Map, Chronic pain based on Brief Pain Inventory (BPI) pain intensity score at 180 days post surgery, Clinically important adverse events, Healthcare Utilization related to pain at 1 month, Healthcare Utilization related to pain at 6 months, PROMIS Pain Interference 4a, PROMIS Preference score 29+2 Profile v2.1