Study details
Enrolling now
Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma
City of Hope Medical Center
NCT IDNCT05800405ClinicalTrials.gov data as of Apr 2026
Phase
EARLY_PHASE1
Target enrollment
9
Study length
about 2.5 years
Ages
18+
Locations
1 site in CA
About this study
This trial is testing if giving radiation therapy before a type of immunotherapy called CAR T-cell infusion can help people with relapsed or refractory large B-cell lymphoma. The goal is to see if this bridging therapy improves treatment outcomes and reduces side effects.
Based on ClinicalTrials.gov records.
What participants do
- 1.Receive Chimeric Antigen Receptor T-Cell Therapy
- 2.Receive External Beam Radiation Therapy
- 3.Undergo Biospecimen Collection
- +3 more
PhaseEARLY_Phase 1
DrugChimeric Antigen Receptor T-Cell Therapy
Participation effort
Estimated from trial records. Details can vary by site.
Time + visits
Low15%
Logistics
Moderate50%
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
Drug classes
cell therapy
Endpoints
Secondary: Complete response rate, Incidence of AEs, Local control, Objective response rate, Overall survival, Progression free survival
Procedures
diagnostic, imaging, radiation, therapy