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Study details
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Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

Medical University of South Carolina
NCT IDNCT05855369ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2/3

Target enrollment

180

Study length

about 4.7 years

Ages

18–65

Locations

1 site in SC

About this study

This trial is testing whether two at-home treatments, smell training and non-invasive trigeminal nerve stimulation, can improve the sense of smell in people with long COVID. Participants will conduct daily at-home treatment sessions and attend trial visits to complete questionnaires over 12 weeks.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Active Smell Training (ST)
  • 2.Placebo Smell Training (PBO)
  • 3.Use Trigeminal Nerve Stimulation (TNS)
PhasePhase 2/Phase 3
Primary goalChange in Olfactory-related Quality of Life from Baseline to 4 and 12 Weeks

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low7%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Change in Olfactory-related Quality of Life from Baseline to 4 and 12 Weeks

Secondary: Change in Cognitive Function from Baseline to 4 and 12 Weeks, Change in Long COVID Symptoms from Baseline to 4 and 12 Weeks, Change in Sleep Quality from Baseline to 4 and 12 Weeks, Change in Symptoms of Anxiety from Baseline to 4 and 12 Weeks, Change in Symptoms of Depression from Baseline to 4 and 12 Weeks