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Study details
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A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Arizona State University
NCT IDNCT05877196ClinicalTrials.gov data as of Apr 2026
Target enrollment

216

Study length

about 5 years

Ages

65+

Locations

1 site in AZ

About this study

Researchers are testing whether aerobic exercise improves fitness in older adults with mild cognitive impairment or early Alzheimer's disease. The trial will compare different types of aerobic exercise, such as chair-based stretching, combined aerobic resistance exercise, high-intensity interval training, and moderate intensity continuous training, to see which one works best over 6 months.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Chair-based Stretch
  • 2.Participate in Combined Aerobic Resistance Exercise (CARE)
  • 3.Participate in High-Intensity Interval Training (HIIT)
  • +1 more

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low6%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Secondary: Behavioral and psychiatric symptoms of dementia (BPSD), Caregiver burden, Physical function, Quality of Life (QoL)

Body systems

Neurology