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Study details
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Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

National Heart, Lung, and Blood Institute (NHLBI)
NCT IDNCT05904093ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

25

Study length

about 1.4 years

Ages

18–65

Locations

1 site in MD

About this study

This trial is testing a treatment called fostamatinib in people with stable sickle cell disease. The goal is to see if this drug is safe and well-tolerated at different doses. Participants will take the drug twice daily for up to 6 weeks, and their health will be monitored through regular clinic visits.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Fostamatinib
PhasePhase 1
DrugFostamatinib
Routeoral
Primary goalThe number of type, incidence, severity and relationship to study treatment of adverse events and serious adverse events

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low14%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

fostamatinib

Drug routes

oral (Oral Tablet)

Endpoints

Primary: The number of type, incidence, severity and relationship to study treatment of adverse events and serious adverse events

Secondary: Number of participants that discontinued fostamatinib due to adverse events following CTCAE.