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Study details
Enrolling now

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Johns Hopkins University
NCT IDNCT06067737ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

90

Study length

about 5.3 years

Ages

21–70

Locations

1 site in MD

About this study

This trial is testing whether psilocybin can help people with opioid use disorder (OUD) stay sober and improve their lives when used alongside buprenorphine treatment. Participants will receive either a high dose or a low dose of psilocybin as an addition to standard outpatient buprenorphine care, and it will last for 1939 days.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Psilocybin
PhasePhase 2
DrugPsilocybin
Routeoral

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug routes

oral

Endpoints

Secondary: Depression as assessed by the Beck Depression Inventory II (BDII), Quality of Life as assessed by the World Health Organization Quality of Life Brief Version (WHOQOL-BREF)

Body systems

Psychiatry / Mental Health