Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Phase 4
148
about 4.3 years
50+
1 site in TN
About this study
Researchers are testing whether a treatment called GlyNAC (a combination of glycine and n-acetylcysteine) reduces oxidative stress and chronic post surgical pain in people undergoing total knee arthroplasty. The trial will last for 1576 days.
Based on ClinicalTrials.gov records.
What participants do
- 1.Take GlyNAC (combination of glycine and n-acetylcysteine)
- 2.Take Placebo
Participation effort
Estimated from trial records. Details can vary by site.
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
acetylcysteine, BLOOD AND BLOOD FORMING ORGANS
oral (Oral Capsule)
Primary: Numeric Rating Scale (NRS) Rating of Worst Pain in the past 24 hours
Secondary: Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR), Mean change in McGill Pain Questionnaire-2 (MPQ-2) ratings of knee pain for average pain over past week of measurement., Numeric Rating Scale (NRS) Rating of Worst Pain in the past 24 hours, Numeric Rating Scale of Average Pain in the past 24 hours, Numeric Rating Scale of Least Pain in the past 24 hours, PROMIS Short Form V1.0 - Pain Interference 8a scale
Musculoskeletal