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Study details
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RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS

University of Minnesota
NCT IDNCT06143293ClinicalTrials.gov data as of Apr 2026
Target enrollment

144

Study length

about 2.6 years

Ages

18+

Locations

5 sites in CA, MN, MO +2

About this study

Researchers are testing a vagus nerve stimulation device to see how it affects the body. The trial will compare acute and chronic effects of this device on various systems in adults with epilepsy or depression who have implanted VNS devices. Participants will receive standard care for their condition along with the VNS device.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Use Vagus nerve stimulation device: acute and chronic administration of investigational vagus nerve stimulation parameters
Primary goalEffect of Vagus nerve stimulation on Head up tilt test-mediated change in Blood pressure

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Effect of Vagus nerve stimulation on Head up tilt test-mediated change in Blood pressure, Effect of Vagus nerve stimulation on Head up tilt test-mediated change in Heart Rate, Effect of Vagus nerve stimulation on Isometric Hand Grip-mediated changes in Blood pressure, Effect of Vagus nerve stimulation on Isometric Hand Grip-mediated changes in Heart Rate, Effect of Vagus nerve stimulation on Post-exercise circulatory occlusion-mediated change in Blood pressure, Effect of Vagus nerve stimulation on Post-exercise circulatory occlusion-mediated change in Heart Rate, Effect of Vagus nerve stimulation on ambulatory diastolic blood pressure, Effect of Vagus nerve stimulation on ambulatory heart rate

Devices

therapeutic

Body systems

Neurology, Psychiatry / Mental Health