Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
Phase 3
250
about 6 years
18+
99 sites in AZ, CA, DE +25
About this study
Researchers are testing whether chemotherapy alone before surgery is as effective as chemotherapy and radiation therapy together before surgery for rectal cancer. The trial also compares the quality of life between these two treatment approaches.
Based on ClinicalTrials.gov records.
What participants do
- 1.Receive Radiation
- 2.Take Capecitabine
- 3.Take Fluoruracil
- +2 more
Participation effort
Estimated from trial records. Details can vary by site.
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
capecitabine, fluorouracil (Antimetabolite; mimics uracil to disrupt DNA/RNA in cancer cells), Antidotes, Deterrents, and Toxicologic Agents (Enzyme Interactions), oxaliplatin
oral (Oral Tablet), injection (Injection)
Primary: Clinical response rate upon re-staging, Quality of Life defined using the LARS score
Secondary: Disease Free Survival, Number and severity of adverse events utilizing CTCAE v5.0, Other QoL functions assessed by subscales of EORTC QLQ-C30, Other QoL functions assessed by subscales of FIQL, Other QoL functions assessed by subscales of subscales of EORTC QLQ-CR29, Overall Survival, Validate the magnetic resonance tumour regression grade (MR-TRG) in patients with T1-T3a rectal cancer
radiation
Oncology