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Study details
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A Study Evaluating FMC-376

Frontier Medicines Corporation
NCT IDNCT06244771ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

403

Study length

about 4.2 years

Ages

18+

Locations

15 sites in CA, FL, IN +7

About this study

Researchers are testing a treatment called FMC-376 for people with certain types of advanced solid tumors that have KRAS G12C mutations. The trial will involve different dose levels and last approximately 1540 days.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take FMC-376
PhasePhase 1/Phase 2
Primary goalAdverse Events (AEs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Adverse Events (AEs), Dose Limiting Toxicities

Secondary: Area Under Blood Concentration-Time Curve (AUC) of FMC-376, Clearance (CL) of FMC-376 from Blood Plasma, Disease Control Rate (DCR), Duration of Response (DOR), Elimination Half-life (t1/2) of FMC-376, Maximum Observed Plasma Concentration (Cmax) of FMC-376, Overall Response Rate (ORR), Overall Survival (OS)

Body systems

Oncology