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Study details
Enrolling now

Nebulized Ketamine vs. Nebulized Fentanyl for Acute Pain

Antonios Likourezos
NCT IDNCT06364540ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

150

Study length

about 2.7 years

Ages

18–120

Locations

1 site in NY

About this study

Researchers are testing whether nebulized ketamine or nebulized fentanyl is better at relieving acute pain in the emergency department. The trial will compare a 0.75 mg/kg dose of ketamine administered via breath-actuated nebulizer (BAN) to a 3 mcg/kg dose of fentanyl administered via breath-actuated nebulizer (BAN).

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Fentanyl
  • 2.Take Ketamine
PhasePhase 4
DrugFentanyl
Routeoral
Primary goalReduction of pain scores on the numeric rating pain scale (NRS)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low11%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

fentanyl, ketamine (NMDA receptor antagonist; induces dissociative anesthesia and analgesia)

Drug routes

oral (Oral Lozenge)

Endpoints

Primary: Reduction of pain scores on the numeric rating pain scale (NRS)

Secondary: Severity of Adverse Events