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Study details
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A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

University College, London
NCT IDNCT06372821ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

10

Study length

about 1.7 years

Ages

21–80

Locations

1 site in MO

About this study

This trial is testing if drug (NIO752) reduces production of tau, a protein that builds up in the brain and causes damage in Alzheimer's disease. The goal is to see if NIO752 can help slow down this process.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Placebo
  • 2.Take NIO752
PhasePhase 1

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low13%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Secondary: Compare rates of tau synthesis and clearance in sporadic AD and ADAD, Comparison of number of Adverse Events reported between participants receiving one dose of NIO752 versus those receiving two doses of NIO752., Number of participants with adverse events [safety and tolerability]

Body systems

Neurology