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Study details
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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

Massachusetts General Hospital
NCT IDNCT06429293ClinicalTrials.gov data as of Apr 2026
Target enrollment

30

Study length

about 3 years

Ages

18–65

Locations

1 site in MA

About this study

Researchers are testing whether cognitive processing therapy (CPT), a type of behavioral treatment, can reduce the risk of cardiovascular disease (CVD) in people with posttraumatic stress disorder (PTSD). The trial will also examine how CPT affects inflammation and autonomic function, and if these changes are linked to alterations in stress-related neural activity.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Cognitive processing therapy
Primary goalHeart rate variability

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low11%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Heart rate variability

Secondary: Axonal integrity of resting neural connections between brain centers using MRI, Blood pressure, Heart rate, MRI based arterial plaque components (such as necrotic tissue, loose connective tissue, and hemorrhage), MRI based arterial wall thickness, MRI based brain activation (via measuring blood flow in important neural centers at rest and with an emotional task using functional MRI), MRI based brain connectivity (by measuring changes in blood flow across networks of neural centers at rest and with an emotional task), MRI based brain structure assessments of volume and density

Body systems

Psychiatry / Mental Health