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Study details
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Open-Label Psilocybin Study

Yale University
NCT IDNCT06442423ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

50

Study length

about 3.2 years

Ages

18+

Locations

1 site in CT

About this study

Researchers are testing the safety of psilocybin in people with mental health symptoms. The trial will last 1170 days and involve giving participants a single dose of psilocybin, followed by follow-up visits at different times.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Psilocybin
PhasePhase 1
DrugPsilocybin
Routeoral
Primary goalAdverse Events Log

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug routes

oral

Endpoints

Primary: Adverse Events Log, Columbia-Suicide Severity Rating Scale (C-SSRS)

Secondary: Beck Depression Inventory (BDI-II), Brief Symptom Inventory (BSI), Hamilton Anxiety Rating Scale (HAM-A), Inventory for Depression and Anxiety Symptoms (IDAS-II), Montgomery-Asberg Depression Scale (MADRS), Quality of Life Enjoyment & Satisfaction Questionnaire - Short Form (Q-LES-Q-SF), Yale-Brown Obsessive-Compulsive Scale-Second Edition (Y-BOCS-II) Symptom Checklist and Severity Scale

Body systems

Psychiatry / Mental Health