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Study details
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A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

AbbVie
NCT IDNCT06461897ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

675

Study length

about 6 years

Ages

2–11

Locations

30 sites in AR, CA, FL +16

About this study

This trial is testing whether oral upadacitinib or subcutaneous dupilumab is better at controlling moderate to severe atopic dermatitis in children aged 2 to under 12. Participants will receive either upadacitinib (taken daily) or dupilumab (given every 2 or 4 weeks), and it will last for about 2 years, with regular visits to monitor their condition and check for side effects.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Dupilumab
  • 2.Take Upadacitinib
PhasePhase 3
DrugDupilumab
Primary goalNumber of Participants with Adverse Events (AEs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

dupilumab, upadacitinib

Drug routes

oral (Oral Solution)

Endpoints

Primary: Number of Participants with Adverse Events (AEs)

Body systems

Dermatology