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Study details
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A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

Eli Lilly and Company
NCT IDNCT06657768ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

88

Study length

about 2.8 years

Ages

45–85

Locations

7 sites in CA, FL, GA +2

About this study

This trial is testing the safety and tolerability of a drug called LY4006895. Part A will give healthy people a single dose, while Part B will give participants with early Alzheimer's disease multiple doses. Blood tests will be done to see how much of the drug gets into the body and how long it stays there.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take LY4006895
  • 2.Take Placebo
PhasePhase 1
Primary goalNumber of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Discontinuations due to Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Discontinuations due to Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration

Secondary: PK: Area Under the Concentration Versus Time Curve (AUC) of LY4006895, PK: Maximum Concentration (Cmax) of LY4006895

Body systems

Neurology