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Study details
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A Study of Lorigerlimab in Participants With Advanced Solid Tumors

MacroGenics
NCT IDNCT06730347ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

60

Study length

about 2.3 years

Ages

18+

Sex

Female only

Locations

7 sites in CA, LA, MI +3

About this study

Researchers are testing lorigerlimab, a medication, in people with advanced solid tumors. The trial will last for 852 days and involve approximately 60 participants who are female only. Participants will receive lorigerlimab by IV infusion every 21 days until cancer progresses or unacceptable side effects occur.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Lorigerlimab
PhasePhase 2
DrugLorigerlimab
Routeintravenous
Primary goalObjective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria as determined by the investigator

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

monoclonal antibody

Drug routes

intravenous

Endpoints

Primary: Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria as determined by the investigator

Secondary: Best percent change from baseline in tumor size, Disease control rate (DCR), Frequency and severity of adverse events (AEs), serious AEs (SAEs), immune-related AEs (irAEs), and AEs leading to dose modifications or treatment discontinuation., Median duration of response (DoR) per RECIST 1.1 criteria, Median progression free survival (PFS) per RECIST 1.1 criteria, Percent change from baseline in tumor size

Body systems

Oncology, Reproductive Health