Study details
Enrolling now
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Duke University
NCT IDNCT06747871ClinicalTrials.gov data as of Apr 2026
Target enrollment
60
Study length
about 2.3 years
Ages
21+
Locations
1 site in NC
About this study
This trial is testing whether switching to very low nicotine cigarettes helps with cravings, withdrawal symptoms, and pain compared to normal nicotine cigarettes in people with chronic pain who smoke daily and are receiving buprenorphine treatment.
Based on ClinicalTrials.gov records.
What participants do
- 1.Participate in Normal Nicotine Cigarettes (NNC)
- 2.Participate in Very Low Nicotine Cigarettes (VLNC)
Primary goalPain as measured by the Brief Pain Inventory (BPI)
Participation effort
Estimated from trial records. Details can vary by site.
Time + visits
Low8%
Logistics
Moderate50%
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
Endpoints
Primary: Pain as measured by the Brief Pain Inventory (BPI), Pain-Smoking Associations as measured by Ecological Momentary Assessment (EMA)
Secondary: Pain and Smoking Inventory (PSI)
Body systems
Psychiatry / Mental Health