A Multicenter Trial to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Phase 1/2
25
about 6 years
40–72
2 sites in KY, NY
About this study
Researchers are testing the safety and tolerability of a treatment called DSP-1083 in people with Parkinson's disease. The trial will also evaluate how well this treatment works clinically. It involves implanting DSP-1083 or performing sham surgery on participants.
Based on ClinicalTrials.gov records.
What participants do
- 1.Undergo Sham surgery treatment
- 2.Use DSP-1083 implantation
Participation effort
Estimated from trial records. Details can vary by site.
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
Primary: Change from baseline in Fluorodopa (F-DOPA) uptake (graft function) neuroimaging parameters., Change from baseline in Head Magnetic Resonance Imaging (MRI) (graft expansion/rejection) neuroimaging parameters., Change from baseline in cognition and neuropsychiatric status as assessed by Mattis Dementia Rating Scale (MDRS)., Change from baseline in cognition and neuropsychiatric status as assessed by Montreal Cognitive Assessment (MoCA)., Incidence and severity of Adverse Events leading to study discontinuation., Incidence and severity of Adverse Events of Special Interest (AESI)., Incidence and severity of Adverse Events., Incidence of Serious Adverse Events (SAE).
surgery
Neurology