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Study details
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A Study of a Novel Precision Medicine Approach for Obesity

Mayo Clinic
NCT IDNCT06814938ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

135

Study length

about 3.8 years

Ages

18–65

Locations

2 sites in FL, MN

About this study

Researchers are testing whether a saliva biomarker can predict how well semaglutide works to treat obesity. The trial will last 1378 days and involve approximately 135 participants. Participants will be assigned to receive either a placebo or semaglutide.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Placebo
  • 2.Take Semaglutide
PhasePhase 4
DrugSemaglutide
Routeoral
Primary goalChange in Total Body Weight at 24 weeks

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

semaglutide (GLP-1 agonist; stimulates insulin release)

Drug routes

oral (Oral Tablet)

Endpoints

Primary: Change in Total Body Weight at 24 weeks

Secondary: Change in Total Body Weight at 3 months, Change in Total Body Weight at 6 months, Change in Waist Circumference

Body systems

Endocrinology