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Study details
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A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

Merck Sharp & Dohme LLC
NCT IDNCT06818643ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

270

Study length

about 6 years

Ages

18+

Locations

4 sites in AL, FL, NJ +1

About this study

This trial is testing a treatment called MK-3120 for people with advanced solid tumors. The goal is to see if this treatment is safe and well-tolerated by participants.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive MK-3120
PhasePhase 1/Phase 2
Primary goalNumber of Participants Who Discontinue Study Treatment Due to an AE

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low8%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Number of Participants Who Discontinue Study Treatment Due to an AE, Number of Participants Who Experience an Adverse Event (AE)

Secondary: AUC of MK-3120 Free Payload, AUC of MK-3120 Total Antibody (TAb), Area Under the Concentration-Time Curve (AUC) of MK-3120 Antibody-Drug Conjugate (ADC), Cmax of MK-3120 Free Payload, Cmax of MK-3120 TAb, Duration Of Response (DOR) Per RECIST 1.1 as Assessed by the Investigator, Maximum Concentration (Cmax) of MK-3120 ADC, Objective Response Rate (ORR) Per Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1) as Assessed by the Investigator

Body systems

Oncology