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Study details
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Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI

University of Florida
NCT IDNCT06821191ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

78

Study length

about 1.8 years

Ages

18+

Locations

1 site in FL

About this study

This trial is testing whether de-escalating dual antiplatelet therapy (DAPT) by reducing the dose of prasugrel or switching from a more potent P2Y12 inhibitor to clopidogrel provides similar benefits for preventing blood clots after heart procedures. The goal is to compare these two methods of DAPT de-escalation and determine if they are equally effective at preventing bleeding while still protecting against clots.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Prasugrel 5 mg
  • 2.Take clopidogrel 75 mg
PhasePhase 4
DrugPrasugrel 5 mg
Routeoral

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low11%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

prasugrel, clopidogrel (Antiplatelet; blocks ADP receptors on platelets to prevent aggregation)

Drug routes

oral (Oral Tablet), oral

Body systems

Cardiology / Heart