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Study details
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CAR T Cell Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia

St. Jude Children's Research Hospital
NCT IDNCT06847269ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

25

Study length

about 5.9 years

Ages

≤21

Locations

1 site in TN

About this study

This trial is testing a new treatment called CAR T cell therapy for people with leukemia that has returned or not responded to other treatments. The treatment involves modifying immune cells to fight cancer cells. Researchers are looking at different doses of chemotherapy drugs, how the body processes these drugs, and how long the CAR T cells last in the body.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive CD19-CAR T cell Infusion
  • 2.Take Cyclophosphamide
  • 3.Take Fludarabine
  • +1 more
PhasePhase 2
DrugCD19-CAR T cell Infusion
Routeinfusion
Primary goalFludarabine Pharmacokinetics

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

cell therapy, cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine, mesna

Drug routes

infusion, oral (Oral Tablet)

Endpoints

Primary: Fludarabine Pharmacokinetics

Body systems

Oncology