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Study details
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Allo HSCT for High Risk Hemoglobinopathies

Masonic Cancer Center, University of Minnesota
NCT IDNCT06872333ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

62

Study length

about 7.5 years

Ages

≤55

Locations

1 site in MN

About this study

Researchers are testing a treatment called allogeneic hematopoietic stem cell transplantation (HSCT) for people with high-risk hemoglobinopathies and other conditions that require frequent blood transfusions. The trial will involve using various medications, including chemotherapy drugs, to prepare the patient before the transplant.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Cell Infusion
  • 2.Receive Total Body Irradiation
  • 3.Take Alemtuzumab
  • +3 more
PhasePhase 2
DrugAlemtuzumab
Routeinjection

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

alemtuzumab, busulfan, cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine, Immunological Agents (Enzyme Inhibitors), sirolimus, tacrolimus, thiotepa

Drug routes

injection (Injection), injection, intravenous, infusion

Endpoints

Secondary: Overall Survival

Procedures

radiation