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Study details
Enrolling now

ACTengine® IMA203 Combined With mRNA-4203

Immatics US, Inc.
NCT IDNCT06946225ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

15

Study length

about 4.1 years

Ages

18+

Locations

4 sites in CA, MA, NY +1

About this study

This trial is testing the safety, tolerability, and anti-tumor activity of IMA203 when combined with different doses of mRNA-4203. It includes adults who have previously been treated for unresectable or metastatic cutaneous melanoma (CM) or synovial sarcoma (SS).

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive IMA203
  • 2.Receive mRNA-4203
PhasePhase 1
Primary goalNumber of participants with dose-limiting toxicities (DLTs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Number of participants with dose-limiting toxicities (DLTs), Number of treatment emergent adverse events (AEs), AEs of special interest, serious AEs (SAEs), changes in laboratory parameters and vital signs, and frequency of dose interruptions, reductions and discontinuations

Secondary: Disease control rate (DCR), Duration of response (DOR), Objective response rate (ORR), Progression-free survival (PFS)

Body systems

Oncology