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Study details
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A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

Exelixis
NCT IDNCT06952010ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

75

Study length

about 2.6 years

Ages

18+

Locations

10 sites in CA, CT, FL +6

About this study

This trial is testing a new treatment called XB628 for people with advanced solid tumors. It's a phase 1 trial, meaning it's the first time this treatment is being tested in humans. The goal is to determine the best dose of XB628 and how well it works.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive XB628
PhasePhase 1
Primary goalNumber of Participants with Dose Limiting Toxicities (DLTs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Number of Participants with Dose Limiting Toxicities (DLTs), Number of Participants with Serious Adverse Events (SAEs), Treatment-emergent Adverse Events (TEAEs), and Adverse Events (AEs) Leading to Dose Withholding, Treatment Discontinuation, or Death

Secondary: Apparent Clearance (CL/F) of XB628, Area Under the Concentration-time Curve (AUC) of XB628, Duration of Response (DOR), Elimination Half-life (T1/2) of XB628, Maximum Plasma Concentration (Cmax) of XB628, Objective Response Rate (ORR), Time to Maximum Concentration (Tmax) of XB628

Body systems

Oncology