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Study details
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A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

Merck Sharp & Dohme LLC
NCT IDNCT06979596ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

250

Study length

about 2.2 years

Ages

18+

Locations

7 sites in AK, FL, LA +3

About this study

This trial is testing if MK-5684, a treatment for cancer, can help people with breast, ovarian, and endometrial cancers live longer without their cancer growing or spreading. Researchers will compare MK-5684 to standard treatments used for these types of cancers.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Dexamethasone/Dexamethasone acetate
  • 2.Take Exemestane
  • 3.Take Fludrocortisone/ Fludrocortisone acetate
  • +3 more
PhasePhase 2
DrugDexamethasone
Routeinjection
Primary goalProgression-Free Survival (PFS) - All Cohorts

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low10%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

dexamethasone, Anti-inflammatory Agent (Corticosteroid Hormone Receptor Agonists), exemestane, fludrocortisone, Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal) (Mineralocorticoid Receptor Agonists), fulvestrant, letrozole (Aromatase inhibitor; prevents estrogen production), Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers) (Progestational Hormone Receptor Agonists)

Drug routes

injection, ocular, oral, oral (Oral Tablet), intramuscular

Endpoints

Primary: Progression-Free Survival (PFS) - All Cohorts

Secondary: Duration of Response (DOR) - All Cohorts, Number of Participants who Discontinue Study Intervention Due to an Adverse Event (AE) - All Cohorts, Number of Participants who Experience One or More Adverse Events (AEs) - All Cohorts, Objective Response Rate (ORR) - All Cohorts, Overall Survival (OS) - All Cohorts

Body systems

Oncology