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Study details
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Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

Duke University
NCT IDNCT06983678ClinicalTrials.gov data as of Apr 2026
Target enrollment

132

Study length

about 4.4 years

Ages

21–65

Locations

1 site in NC

About this study

This trial is testing how smoking withdrawal affects the brain's processing of pain in people with and without chronic pain. The researchers will examine if these changes during withdrawal make it harder to quit smoking. This research could help develop better ways to help people with chronic pain who smoke stop smoking.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Participate in Abstinent fMRI session
  • 2.Participate in Smoking as usual fMRI session
Primary goalDaily pain ratings

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low7%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Daily pain ratings, Daily withdrawal symptoms, Fluctuations in pain ratings vs number of cigarettes smoked, Fluctuations in pain ratings vs smoking urge, Pain intensity ratings to high heat vs neutral temperatures

Procedures

imaging