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Study details
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A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)

SCRI Development Innovations, LLC
NCT IDNCT07011576ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

60

Study length

about 1.8 years

Ages

18+

Locations

14 sites in CO, IL, MD +7

About this study

This trial is testing a treatment with fruquintinib and FOLFIRI in people with metastatic colorectal cancer. The goal is to see if this combination is effective and safe.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin)
  • 2.Take fruquintinib
PhasePhase 2
Drug5-Fluorouracil
Primary goalProgression-Free Survival (PFS) rate at 6 months

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low12%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

fluorouracil (Antimetabolite; mimics uracil to disrupt DNA/RNA in cancer cells), chemotherapy (Antimetabolite; mimics uracil to disrupt DNA/RNA in cancer cells), irinotecan, Antidotes, Deterrents, and Toxicologic Agents (Enzyme Interactions), fruquintinib

Drug routes

oral (Oral Capsule), injection (Injection)

Endpoints

Primary: Progression-Free Survival (PFS) rate at 6 months

Secondary: Disease control response rate (DCR), Duration of response (DoR), Number of participants with treatment emergent adverse events, Overall Response Rate (ORR), Overall Survival (OS)

Body systems

Oncology