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Study details
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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

Hoffmann-La Roche
NCT IDNCT07174310ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

900

Study length

about 5.6 years

Ages

50–85

Locations

29 sites in CA, CO, CT +14

About this study

This trial is testing a treatment called prasinezumab compared to a placebo in people with early-stage Parkinson's disease. The goal is to see if prasinezumab helps manage symptoms, is safe, and how it works in the body.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Placebo
  • 2.Take Prasinezumab
PhasePhase 3
DrugPrasinezumab
Primary goalTime to Confirmed Motor Progression Event on Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III Score

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

monoclonal antibody

Endpoints

Primary: Time to Confirmed Motor Progression Event on Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III Score

Secondary: Change From Baseline in Motor Function as Measured by the MDS-UPDRS Part III off Medication Score, Percentage of Participants With Adverse Events of Special Interest (AESI), Percentage of Participants With Treatment Emergent Adverse Events (TEAEs)

Body systems

Neurology